We determined that the Department’s oversight of its drug interdiction efforts did not align with the Office of National Drug Control Policy’s (ONDCP) National Drug Control Strategy. . This occurred because DHS lacks formal oversight roles and responsibilities to ensure its drug interdiction performance activities met both ONDCP and legislative requirements. As a result, DHS could not ensure its drug interdiction efforts met required national drug control outcomes nor accurately assess the impact of the approximately $4.2 billion it spends annually on drug control activities. We made two recommendations that, if implemented, will improve DHS’ drug interdiction efforts. DHS concurred with both recommendations.