U .S. Customs and Border Protection's (CBP) Houston Seaport is the fifth largest port for arriving containers and the largest petrochemical complex in the Nation. CBP is responsible for identifying high-risk cargo shipments arriving at the port that pose a possible threat to national security. We conducted this review to determine whether the Houston Seaport complied with CBP's National Maritime Targeting Policy (NMTP) and Cargo Enforcement Reporting and Tracking System (CERTS) Port Guidance. The Houston Seaport generally complied with the NMTP and CERTS Port Guidance. However, CBP could improve its documentation of waivers and exceptions to mandatory examinations of high-risk cargo. In addition, CBP could improve access controls for authorizing Port Director waivers within CERTS.